Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL636727

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Potency against rat brain adenosine A1 receptor
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine receptor A1 (CHEMBL318)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.
Olsson RA, Kusachi S, Thompson RD, Ukena D, Padgett W, Daly JW.
J Med Chem (1986) 29 : 1683 -1689
PubMed 3018244 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 7.55 9.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2094085 1 9.28
CHEMBL2094086 1 9.21
CHEMBL605863 1 9.07
CHEMBL604834 1 9.00
CHEMBL2094084 1 8.96
CHEMBL606503 1 8.92
CHEMBL605449 1 8.82
CHEMBL604207 1 8.77
CHEMBL2093998 1 8.62
CHEMBL603990 1 8.34
CHEMBL464859 NECA 1 7.99
CHEMBL261482 1 7.98
CHEMBL603358 1 7.77
CHEMBL605239 1 7.70
CHEMBL2093997 1 7.58
CHEMBL603571 1 7.54
CHEMBL2093996 1 7.51
CHEMBL2093995 1 7.48
CHEMBL606290 1 7.27
CHEMBL606289 1 7.17
CHEMBL605866 1 7.16
CHEMBL519809 1 6.98
CHEMBL606504 1 6.98
CHEMBL2094082 1 6.98
CHEMBL605867 1 6.92
CHEMBL603359 1 5.85
CHEMBL605029 1 5.77
CHEMBL606288 1 5.02
CHEMBL603573 1 5.00
CHEMBL603360 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2094085 IC50 = 0.52 nM 9.28
CHEMBL2094086 IC50 = 0.62 nM 9.21
CHEMBL605863 IC50 = 0.86 nM 9.07
CHEMBL604834 IC50 = 1.0 nM 9.00
CHEMBL2094084 IC50 = 1.1 nM 8.96
CHEMBL606503 IC50 = 1.2 nM 8.92
CHEMBL605449 IC50 = 1.5 nM 8.82
CHEMBL604207 IC50 = 1.7 nM 8.77
CHEMBL2093998 IC50 = 2.4 nM 8.62
CHEMBL603990 IC50 = 4.6 nM 8.34
CHEMBL464859 NECA IC50 = 10.2 nM 7.99
CHEMBL261482 IC50 = 10.5 nM 7.98
CHEMBL603358 IC50 = 17.0 nM 7.77
CHEMBL605239 IC50 = 20.0 nM 7.70
CHEMBL2093997 IC50 = 26.0 nM 7.58
CHEMBL603571 IC50 = 29.0 nM 7.54
CHEMBL2093996 IC50 = 31.0 nM 7.51
CHEMBL2093995 IC50 = 33.0 nM 7.48
CHEMBL606290 IC50 = 54.0 nM 7.27
CHEMBL606289 IC50 = 68.0 nM 7.17
CHEMBL605866 IC50 = 70.0 nM 7.16
CHEMBL519809 IC50 = 105.0 nM 6.98
CHEMBL606504 IC50 = 104.0 nM 6.98
CHEMBL2094082 IC50 = 105.0 nM 6.98
CHEMBL605867 IC50 = 120.0 nM 6.92
CHEMBL603359 IC50 = 1400.0 nM 5.85
CHEMBL605029 IC50 = 1700.0 nM 5.77
CHEMBL606288 IC50 = 9600.0 nM 5.02
CHEMBL603573 IC50 = 10000.0 nM 5.00
CHEMBL603360 IC50 = 13000.0 nM 4.89