Assay Detail
Binding
CHEMBL636774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit H+/K+ stimulated ATPase activity in lympholised gastric vesicles
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Potassium-transporting ATPase alpha chain 1 (CHEMBL3919) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
4-(2-PYRTOYL)-5-phenylthiazoles as novel non-bicyclic reversible inhibitors of the gastric H+/K+-atpase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.24 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294877 | — | — | 1 | 6.01 |
| CHEMBL153638 | — | — | 1 | 5.66 |
| CHEMBL153637 | — | — | 1 | 5.54 |
| CHEMBL356199 | — | — | 1 | 5.31 |
| CHEMBL151183 | — | — | 1 | 5.09 |
| CHEMBL151334 | — | — | 1 | 5.02 |
| CHEMBL149912 | — | — | 1 | 4.90 |
| CHEMBL347117 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294877 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL153638 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL153637 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL356199 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL151183 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL151334 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL149912 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL347117 | — | IC50 | = | 42300.0 | nM | 4.37 |