Assay Detail
Functional
CHEMBL636815
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Negative chronotropic activity for A1 Adenosine receptor in spontaneously beating rat atria
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.32 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113404 | — | — | 1 | 6.32 |
| CHEMBL2113419 | — | — | 1 | - |
| CHEMBL2113416 | — | — | 1 | - |
| CHEMBL2113486 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113404 | — | EC50 | = | 475.0 | nM | 6.32 |
| CHEMBL2113419 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2113416 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2113486 | — | EC50 | > | 10000.0 | nM | - |