Assay Detail
Functional
CHEMBL636816
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Stimulation of [35S]GTP-gamma-S, binding to adenosine A1 receptor of rat cerebral cortical membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.70 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 7.69 |
| CHEMBL27952 | — | — | 1 | 7.00 |
| CHEMBL284216 | — | — | 1 | 6.84 |
| CHEMBL66393 | — | — | 1 | 6.47 |
| CHEMBL27809 | — | — | 1 | 6.17 |
| CHEMBL417292 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | EC50 | = | 20.3 | nM | 7.69 |
| CHEMBL27952 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL284216 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL66393 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL27809 | — | EC50 | = | 684.0 | nM | 6.17 |
| CHEMBL417292 | — | EC50 | = | 940.0 | nM | 6.03 |