Assay Detail
Binding
CHEMBL636823
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Inhibitory activity against acetylcholinesterase in rat brain
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acetylcholinesterase inhibition by fused dihydroquinazoline compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.38 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.03 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.70 |
| CHEMBL433041 | EPTASTIGMINE | 2.0 | 1 | 6.22 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.75 |
| CHEMBL445130 | — | — | 1 | 5.72 |
| CHEMBL161880 | — | — | 1 | 5.32 |
| CHEMBL165726 | — | — | 1 | 5.03 |
| CHEMBL165304 | — | — | 1 | 4.82 |
| CHEMBL349977 | — | — | 1 | 4.79 |
| CHEMBL355821 | — | — | 1 | 4.75 |
| CHEMBL166194 | — | — | 1 | 4.45 |
| CHEMBL162734 | — | — | 1 | 4.00 |
| CHEMBL163362 | — | — | 1 | - |
| CHEMBL165292 | — | — | 1 | - |
| CHEMBL166359 | — | — | 1 | - |
| CHEMBL350496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL95 | TACRINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL433041 | EPTASTIGMINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL445130 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL161880 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL165726 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL165304 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL349977 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL355821 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL166194 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL162734 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL163362 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL165292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL166359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL350496 | — | IC50 | > | 100000.0 | nM | - |