Assay Detail
Binding
CHEMBL636825
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Inhibition of acetylcholinesterase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.05 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.64 |
| CHEMBL51934 | VELNACRINE | 2.0 | 1 | 5.89 |
| CHEMBL166854 | — | — | 1 | 5.34 |
| CHEMBL354304 | — | — | 1 | 5.27 |
| CHEMBL354601 | — | — | 1 | 4.97 |
| CHEMBL172733 | — | — | 1 | 4.83 |
| CHEMBL349428 | — | — | 1 | 4.60 |
| CHEMBL169407 | — | — | 1 | 4.56 |
| CHEMBL168213 | — | — | 1 | 4.21 |
| CHEMBL172102 | — | — | 1 | 4.19 |
| CHEMBL355059 | — | — | 1 | - |
| CHEMBL354617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL51934 | VELNACRINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL166854 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL354304 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL354601 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL172733 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL349428 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL169407 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL168213 | — | IC50 | = | 62100.0 | nM | 4.21 |
| CHEMBL172102 | — | IC50 | = | 64400.0 | nM | 4.19 |
| CHEMBL355059 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL354617 | — | IC50 | > | 100000.0 | nM | - |