Assay Detail
Binding
CHEMBL636826
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Compound was tested in vitro for inhibitory activity against Acetylcholinesterase in rat cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Acetylcholinesterase inhibition by tacrine analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.14 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.70 |
| CHEMBL60167 | — | — | 1 | 6.32 |
| CHEMBL89012 | — | — | 1 | 5.40 |
| CHEMBL89011 | — | — | 1 | - |
| CHEMBL50608 | — | — | 1 | - |
| CHEMBL314800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL60167 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL89012 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL89011 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL50608 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL314800 | — | IC50 | > | 100000.0 | nM | - |