Assay Detail
Binding
CHEMBL636829
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In vitro inhibition against acetylcholinesterase in rat striata.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.11 | 7.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298577 | — | — | 1 | 7.93 |
| CHEMBL50309 | — | — | 1 | 6.54 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.50 |
| CHEMBL298154 | — | — | 1 | 6.08 |
| CHEMBL51063 | — | — | 1 | 5.89 |
| CHEMBL50264 | — | — | 1 | 5.75 |
| CHEMBL54086 | — | — | 1 | 5.75 |
| CHEMBL50462 | — | — | 1 | 5.70 |
| CHEMBL50578 | — | — | 1 | 5.47 |
| CHEMBL51934 | VELNACRINE | 2.0 | 1 | 5.40 |
| CHEMBL53978 | — | — | 1 | 5.40 |
| CHEMBL50735 | — | — | 1 | 5.23 |
| CHEMBL50736 | — | — | 1 | 5.22 |
| CHEMBL298896 | — | — | 1 | 5.12 |
| CHEMBL299771 | — | — | 1 | 5.06 |
| CHEMBL300315 | — | — | 1 | 4.99 |
| CHEMBL298685 | — | — | 1 | 4.96 |
| CHEMBL1794988 | — | — | 1 | 4.90 |
| CHEMBL52608 | — | — | 1 | 4.88 |
| CHEMBL50263 | — | — | 1 | 4.88 |
| CHEMBL54186 | — | — | 1 | 4.88 |
| CHEMBL53182 | — | — | 1 | 4.88 |
| CHEMBL53598 | — | — | 1 | 4.85 |
| CHEMBL1794987 | — | — | 1 | 4.82 |
| CHEMBL298674 | — | — | 1 | 4.78 |
| CHEMBL299147 | — | — | 1 | 4.74 |
| CHEMBL53973 | — | — | 1 | 4.70 |
| CHEMBL53715 | — | — | 1 | 4.68 |
| CHEMBL53239 | — | — | 1 | 4.68 |
| CHEMBL53240 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298577 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL50309 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL95 | TACRINE | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL298154 | — | IC50 | = | 823.0 | nM | 6.08 |
| CHEMBL51063 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL50264 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL54086 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL50462 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL50578 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL51934 | VELNACRINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL53978 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL50735 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL50736 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL298896 | — | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL299771 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL300315 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL298685 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL1794988 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL53182 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL50263 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL52608 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL54186 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL53598 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL1794987 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL298674 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL299147 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL53973 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL53715 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL53239 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL53240 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL51168 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL52181 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL53830 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL52967 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL53666 | — | IC50 | = | 49300.0 | nM | 4.31 |
| CHEMBL1794989 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL50410 | — | IC50 | = | 68200.0 | nM | 4.17 |
| CHEMBL50322 | — | IC50 | = | 87800.0 | nM | 4.06 |