Assay Detail
Binding
CHEMBL636831
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In vitro inhibitory effect on rat Acetylcholinesterase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.92 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.77 |
| CHEMBL100718 | — | — | 1 | 8.22 |
| CHEMBL317541 | — | — | 1 | 7.89 |
| CHEMBL100020 | — | — | 1 | 7.89 |
| CHEMBL430679 | — | — | 1 | 7.82 |
| CHEMBL431058 | — | — | 1 | 7.58 |
| CHEMBL100819 | — | — | 1 | 7.52 |
| CHEMBL101518 | — | — | 1 | 7.52 |
| CHEMBL101940 | — | — | 1 | 7.26 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.20 |
| CHEMBL102142 | — | — | 1 | 7.11 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.10 |
| CHEMBL100510 | — | — | 1 | 7.00 |
| CHEMBL100334 | — | — | 1 | 6.92 |
| CHEMBL101809 | — | — | 1 | 6.64 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.27 |
| CHEMBL101028 | — | — | 1 | 6.00 |
| CHEMBL101155 | — | — | 1 | 5.96 |
| CHEMBL99605 | — | — | 1 | 5.85 |
| CHEMBL329518 | — | — | 1 | 5.82 |
| CHEMBL101988 | — | — | 1 | 5.75 |
| CHEMBL98497 | — | — | 1 | 5.64 |
| CHEMBL99606 | — | — | 1 | 5.40 |
| CHEMBL420827 | — | — | 1 | - |
| CHEMBL329733 | — | — | 1 | - |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL100718 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL317541 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL100020 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL430679 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL431058 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL100819 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL101518 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL101940 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL95 | TACRINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL102142 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL100510 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL100334 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL101809 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL101028 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL101155 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL99605 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL329518 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL101988 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL98497 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL99606 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL420827 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL329733 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL395280 | HUPERZINE A | IC50 | - | nM | - |