Assay Detail
Binding
CHEMBL636834
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Inhibition of guinea pig acetylcholinesterase
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.24 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54126 | NEOSTIGMINE BROMIDE | 2.0 | 1 | 7.66 |
| CHEMBL154211 | — | — | 1 | 7.52 |
| CHEMBL154972 | — | — | 1 | 7.14 |
| CHEMBL155111 | — | — | 1 | 7.10 |
| CHEMBL1203534 | — | — | 1 | 7.02 |
| CHEMBL1203538 | — | — | 1 | 6.92 |
| CHEMBL347539 | — | — | 1 | 6.55 |
| CHEMBL154263 | — | — | 1 | 6.54 |
| CHEMBL152260 | — | — | 1 | 6.43 |
| CHEMBL154366 | — | — | 1 | 6.43 |
| CHEMBL345849 | — | — | 1 | 6.41 |
| CHEMBL154689 | — | — | 1 | 6.41 |
| CHEMBL346733 | — | — | 1 | 6.37 |
| CHEMBL155322 | — | — | 1 | 6.27 |
| CHEMBL1203539 | — | — | 1 | 6.22 |
| CHEMBL155392 | — | — | 1 | 6.20 |
| CHEMBL1790041 | RANITIDINE | 4.0 | 1 | 6.19 |
| CHEMBL1203537 | — | — | 1 | 6.08 |
| CHEMBL156659 | — | — | 1 | 5.92 |
| CHEMBL157208 | — | — | 1 | 5.82 |
| CHEMBL153311 | — | — | 1 | 5.68 |
| CHEMBL152722 | — | — | 1 | 5.51 |
| CHEMBL1203535 | — | — | 1 | 5.48 |
| CHEMBL349127 | — | — | 1 | 5.35 |
| CHEMBL153821 | — | — | 1 | 5.35 |
| CHEMBL154950 | — | — | 1 | 5.03 |
| CHEMBL154433 | — | — | 1 | 4.96 |
| CHEMBL155495 | — | — | 1 | - |
| CHEMBL347729 | — | — | 1 | - |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54126 | NEOSTIGMINE BROMIDE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL154211 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL154972 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL155111 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1203534 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1203538 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL347539 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL154263 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL152260 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL154366 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL345849 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL154689 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL346733 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL155322 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1203539 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL155392 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1790041 | RANITIDINE | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1203537 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL156659 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL157208 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL153311 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL152722 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1203535 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL349127 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL153821 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL154950 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL154433 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL155495 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL347729 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | > | 20000.0 | nM | - |