Assay Detail
Binding
CHEMBL636835
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Inhibition against acetylcholinesterase (AChE)
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.83 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158637 | — | — | 1 | 8.82 |
| CHEMBL158860 | — | — | 1 | 8.59 |
| CHEMBL353129 | — | — | 1 | 8.30 |
| CHEMBL161100 | — | — | 1 | 8.22 |
| CHEMBL159704 | — | — | 1 | 8.12 |
| CHEMBL159474 | — | — | 1 | 8.00 |
| CHEMBL159878 | — | — | 1 | 7.96 |
| CHEMBL440547 | — | — | 1 | 7.96 |
| CHEMBL100020 | — | — | 1 | 7.89 |
| CHEMBL159702 | — | — | 1 | 7.85 |
| CHEMBL159576 | — | — | 1 | 7.82 |
| CHEMBL161139 | — | — | 1 | 7.70 |
| CHEMBL160095 | — | — | 1 | 7.66 |
| CHEMBL159813 | — | — | 1 | 7.48 |
| CHEMBL159634 | — | — | 1 | 7.40 |
| CHEMBL349694 | — | — | 1 | 7.10 |
| CHEMBL160088 | — | — | 1 | 7.00 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.96 |
| CHEMBL160008 | — | — | 1 | 6.82 |
| CHEMBL161269 | — | — | 1 | 6.68 |
| CHEMBL159454 | — | — | 1 | 6.68 |
| CHEMBL161190 | — | — | 1 | 6.60 |
| CHEMBL161003 | — | — | 1 | 6.58 |
| CHEMBL161274 | — | — | 1 | 6.52 |
| CHEMBL350644 | — | — | 1 | 6.46 |
| CHEMBL159401 | — | — | 1 | 6.40 |
| CHEMBL161199 | — | — | 1 | 6.40 |
| CHEMBL160009 | — | — | 1 | 6.38 |
| CHEMBL161607 | — | — | 1 | 6.30 |
| CHEMBL161248 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158637 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL158860 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL353129 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL161100 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL159704 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL159474 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL159878 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL440547 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL100020 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL159702 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL159576 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL161139 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL160095 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL159813 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL159634 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL349694 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL160088 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL95 | TACRINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL160008 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL161269 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL159454 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL161190 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL161003 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL161274 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL350644 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL159401 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL161199 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL160009 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL161607 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL161248 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL159800 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL161179 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL347813 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL161062 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL161795 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL159779 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL162747 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL351536 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL159353 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL349043 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL159553 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL161149 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL423777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL159701 | — | IC50 | > | 10000.0 | nM | - |