Assay Detail
Binding
CHEMBL636836
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In vitro inhibition of acetylcholinesterase, isolated from rat brain.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.39 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330883 | — | — | 1 | 7.41 |
| CHEMBL118752 | — | — | 1 | 7.25 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.11 |
| CHEMBL431844 | — | — | 1 | 6.62 |
| CHEMBL60167 | — | — | 1 | 6.46 |
| CHEMBL119390 | — | — | 1 | 5.46 |
| CHEMBL118968 | — | — | 1 | 5.04 |
| CHEMBL119389 | — | — | 1 | 4.60 |
| CHEMBL89012 | — | — | 1 | 4.43 |
| CHEMBL118139 | — | — | 1 | 4.42 |
| CHEMBL118033 | — | — | 1 | 4.32 |
| CHEMBL115697 | — | — | 1 | 4.16 |
| CHEMBL119634 | — | — | 1 | 4.16 |
| CHEMBL119528 | — | — | 1 | 4.04 |
| CHEMBL325203 | — | — | 1 | - |
| CHEMBL331637 | — | — | 1 | - |
| CHEMBL333011 | — | — | 1 | - |
| CHEMBL332454 | — | — | 1 | - |
| CHEMBL115580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330883 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL118752 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL95 | TACRINE | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL431844 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL60167 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL119390 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL118968 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL119389 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL89012 | — | IC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL118139 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL118033 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL115697 | — | IC50 | = | 69400.0 | nM | 4.16 |
| CHEMBL119634 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL119528 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL325203 | — | IC50 | = | 391100.0 | nM | - |
| CHEMBL331637 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL333011 | — | IC50 | = | 144100.0 | nM | - |
| CHEMBL332454 | — | IC50 | = | 166100.0 | nM | - |
| CHEMBL115580 | — | IC50 | = | 134000.0 | nM | - |