Assay Detail
Functional
CHEMBL636938
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Inhibition of proliferation AG1523 (human fibroblast) cell line.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AG1523 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.28 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326961 | — | — | 1 | 7.20 |
| CHEMBL116582 | — | — | 1 | 6.69 |
| CHEMBL326828 | — | — | 1 | 6.59 |
| CHEMBL411432 | — | — | 1 | 6.54 |
| CHEMBL323813 | — | — | 1 | 6.48 |
| CHEMBL273619 | — | — | 1 | 6.46 |
| CHEMBL116934 | — | — | 1 | 6.42 |
| CHEMBL117473 | — | — | 1 | 6.31 |
| CHEMBL116510 | — | — | 1 | 6.22 |
| CHEMBL116646 | — | — | 1 | 6.21 |
| CHEMBL117712 | — | — | 1 | 6.19 |
| CHEMBL323908 | — | — | 1 | 6.17 |
| CHEMBL117593 | — | — | 1 | 6.04 |
| CHEMBL324612 | — | — | 1 | 6.00 |
| CHEMBL116647 | — | — | 1 | 5.82 |
| CHEMBL325453 | — | — | 1 | 5.81 |
| CHEMBL117866 | — | — | 1 | 5.55 |
| CHEMBL114464 | — | — | 1 | - |
| CHEMBL325023 | — | — | 1 | - |
| CHEMBL119106 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326961 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL116582 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL326828 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL411432 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL323813 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL273619 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL116934 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL117473 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL116510 | — | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL116646 | — | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL117712 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL323908 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL117593 | — | IC50 | = | 905.0 | nM | 6.04 |
| CHEMBL324612 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL116647 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL325453 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL117866 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL114464 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL325023 | — | IC50 | > | 21000.0 | nM | - |
| CHEMBL119106 | — | IC50 | > | 17000.0 | nM | - |