Assay Detail
Binding
CHEMBL636941
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Inhibitory activity against Acyl-coenzyme A:cholesterol acyltransferase in macrophages
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.25 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135450 | — | — | 1 | 5.50 |
| CHEMBL422286 | — | — | 1 | 5.29 |
| CHEMBL135534 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135450 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL422286 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL135534 | — | IC50 | = | 11000.0 | nM | 4.96 |