Assay Detail
Binding
CHEMBL637615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Acetylcholinesterase in monkey red blood cell
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.24 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.12 |
| CHEMBL319451 | — | — | 1 | 6.32 |
| CHEMBL1127 | 7-HYDROXYTACRINE | — | 1 | 6.12 |
| CHEMBL51934 | VELNACRINE | 2.0 | 1 | 6.02 |
| CHEMBL318026 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL319451 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL1127 | 7-HYDROXYTACRINE | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL51934 | VELNACRINE | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL318026 | — | IC50 | = | 2300.0 | nM | 5.64 |