Assay Detail
Binding
CHEMBL637699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CHA from human Adenosine A1 receptor expressed in CHO cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.43 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67026 | — | — | 1 | 6.60 |
| CHEMBL17127 | SCH-58261 | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67026 | — | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL17127 | SCH-58261 | Ki | = | 549.0 | nM | 6.26 |