Assay Detail
Binding
CHEMBL637705
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Binding affinity against adenosine A1 receptors from rat brain membranes using [3H]CCPA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.01 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 9.10 |
| CHEMBL139000 | (R)-PIA | — | 1 | 8.89 |
| CHEMBL464859 | NECA | — | 1 | 8.09 |
| CHEMBL319387 | — | — | 1 | 7.80 |
| CHEMBL2113510 | — | — | 1 | 7.67 |
| CHEMBL2113496 | — | — | 1 | 7.60 |
| CHEMBL2113507 | — | — | 1 | 7.55 |
| CHEMBL410873 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL139000 | (R)-PIA | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL464859 | NECA | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL319387 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL2113510 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL2113496 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL2113507 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL410873 | — | Ki | = | 43.9 | nM | 7.36 |