Assay Detail
Binding
CHEMBL637713
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for adenosine A1 receptor, was assessed from the ability to displace [3H]DPCPX (with 1 mM GTP) from rat cortical membranes.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.24 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790716 | — | — | 1 | 5.96 |
| CHEMBL1790734 | — | — | 1 | 5.88 |
| CHEMBL1790714 | — | — | 1 | 5.85 |
| CHEMBL1790736 | — | — | 1 | 5.59 |
| CHEMBL1790737 | — | — | 1 | 5.44 |
| CHEMBL1790731 | — | — | 1 | 5.03 |
| CHEMBL1790733 | — | — | 1 | 4.99 |
| CHEMBL1790739 | — | — | 1 | 4.84 |
| CHEMBL1790730 | — | — | 1 | 4.78 |
| CHEMBL1790715 | — | — | 1 | 4.69 |
| CHEMBL1790735 | — | — | 1 | 4.63 |
| CHEMBL1790738 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790716 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL1790734 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL1790714 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL1790736 | — | Ki | = | 2560.0 | nM | 5.59 |
| CHEMBL1790737 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL1790731 | — | Ki | = | 9310.0 | nM | 5.03 |
| CHEMBL1790733 | — | Ki | = | 10200.0 | nM | 4.99 |
| CHEMBL1790739 | — | Ki | = | 14300.0 | nM | 4.84 |
| CHEMBL1790730 | — | Ki | = | 16700.0 | nM | 4.78 |
| CHEMBL1790715 | — | Ki | = | 20400.0 | nM | 4.69 |
| CHEMBL1790735 | — | Ki | = | 23600.0 | nM | 4.63 |
| CHEMBL1790738 | — | Ki | = | 134000.0 | nM | - |