Assay Detail
Binding
CHEMBL637714
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Binding affinity for adenosine A1 receptor, was assessed from the ability to displace [3H]-DPCPX (without GTP) from rat cortical membranes.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.23 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790734 | — | — | 1 | 6.81 |
| CHEMBL1790733 | — | — | 1 | 6.67 |
| CHEMBL1790737 | — | — | 1 | 6.61 |
| CHEMBL1790716 | — | — | 1 | 6.43 |
| CHEMBL1790730 | — | — | 1 | 6.38 |
| CHEMBL1790736 | — | — | 1 | 6.30 |
| CHEMBL1790735 | — | — | 1 | 6.28 |
| CHEMBL1790731 | — | — | 1 | 6.23 |
| CHEMBL1790714 | — | — | 1 | 6.18 |
| CHEMBL1790739 | — | — | 1 | 6.14 |
| CHEMBL1790715 | — | — | 1 | 6.11 |
| CHEMBL1790738 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790734 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL1790733 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL1790737 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL1790716 | — | Ki | = | 369.0 | nM | 6.43 |
| CHEMBL1790730 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL1790736 | — | Ki | = | 497.0 | nM | 6.30 |
| CHEMBL1790735 | — | Ki | = | 524.0 | nM | 6.28 |
| CHEMBL1790731 | — | Ki | = | 586.0 | nM | 6.23 |
| CHEMBL1790714 | — | Ki | = | 659.0 | nM | 6.18 |
| CHEMBL1790739 | — | Ki | = | 724.0 | nM | 6.14 |
| CHEMBL1790715 | — | Ki | = | 769.0 | nM | 6.11 |
| CHEMBL1790738 | — | Ki | = | 25200.0 | nM | 4.60 |