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Assay Detail

CHEMBL637741

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Binding
Inhibitory activity against mouse brain Acetylcholinesterase
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL3198)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives.
Sugimoto H, Tsuchiya Y, Sugumi H, Higurashi K, Karibe N, Iimura Y, Sasaki A, Kawakami Y, Nakamura T, Araki S.
J Med Chem (1990) 33 : 1880 -1887
PubMed 2362265 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 6.92 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL56960 1 9.52
CHEMBL299708 1 9.22
CHEMBL54058 1 9.22
CHEMBL59583 1 7.54
CHEMBL55312 1 7.46
CHEMBL55968 1 7.41
CHEMBL56001 1 7.29
CHEMBL55323 1 7.26
CHEMBL299313 1 7.16
CHEMBL56706 1 7.07
CHEMBL54835 1 7.06
CHEMBL56586 1 6.92
CHEMBL57696 1 6.89
CHEMBL56818 1 6.81
CHEMBL56470 1 6.77
CHEMBL298603 1 6.75
CHEMBL55253 1 6.75
CHEMBL55466 1 6.64
CHEMBL294242 1 6.33
CHEMBL55131 1 6.28
CHEMBL55014 1 6.25
CHEMBL56079 1 6.10
CHEMBL56368 1 6.06
CHEMBL292440 1 6.03
CHEMBL291918 1 6.00
CHEMBL301243 1 5.80
CHEMBL294413 1 4.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL56960 IC50 = 0.3 nM 9.52
CHEMBL299708 IC50 = 0.6 nM 9.22
CHEMBL54058 IC50 = 0.6 nM 9.22
CHEMBL59583 IC50 = 29.0 nM 7.54
CHEMBL55312 IC50 = 35.0 nM 7.46
CHEMBL55968 IC50 = 39.0 nM 7.41
CHEMBL56001 IC50 = 51.0 nM 7.29
CHEMBL55323 IC50 = 55.0 nM 7.26
CHEMBL299313 IC50 = 69.0 nM 7.16
CHEMBL56706 IC50 = 85.0 nM 7.07
CHEMBL54835 IC50 = 88.0 nM 7.06
CHEMBL56586 IC50 = 120.0 nM 6.92
CHEMBL57696 IC50 = 130.0 nM 6.89
CHEMBL56818 IC50 = 155.0 nM 6.81
CHEMBL56470 IC50 = 170.0 nM 6.77
CHEMBL298603 IC50 = 180.0 nM 6.75
CHEMBL55253 IC50 = 180.0 nM 6.75
CHEMBL55466 IC50 = 230.0 nM 6.64
CHEMBL294242 IC50 = 470.0 nM 6.33
CHEMBL55131 IC50 = 530.0 nM 6.28
CHEMBL55014 IC50 = 560.0 nM 6.25
CHEMBL56079 IC50 = 800.0 nM 6.10
CHEMBL56368 IC50 = 880.0 nM 6.06
CHEMBL292440 IC50 = 940.0 nM 6.03
CHEMBL291918 IC50 = 1000.0 nM 6.00
CHEMBL301243 IC50 = 1600.0 nM 5.80
CHEMBL294413 IC50 = 46000.0 nM 4.34