Assay Detail
Binding
CHEMBL637746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.78 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.46 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 8.77 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL14 | CARBACHOL | Ki | = | 8.0 | nM | 8.10 |