Assay Detail
ADMET
CHEMBL637819
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Antagonist dissociation constant in dog prostate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Canis lupus familiaris |
| Tissue | Prostate gland |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.53 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40650 | — | — | 1 | 9.11 |
| CHEMBL291262 | — | — | 1 | 8.78 |
| CHEMBL2112073 | — | — | 1 | 8.63 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 7.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40650 | — | Kd | = | 0.7762 | nM | 9.11 |
| CHEMBL291262 | — | Kd | = | 1.66 | nM | 8.78 |
| CHEMBL2112073 | — | Kd | = | 2.344 | nM | 8.63 |
| CHEMBL707 | DOXAZOSIN | Kd | = | 25.7 | nM | 7.59 |