Assay Detail
ADMET
CHEMBL637821
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Antagonist dissociation constant in rat spleen
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.20 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 9.51 |
| CHEMBL40650 | — | — | 1 | 7.89 |
| CHEMBL291262 | — | — | 1 | 7.79 |
| CHEMBL2112073 | — | — | 1 | 7.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL707 | DOXAZOSIN | Kd | = | 0.309 | nM | 9.51 |
| CHEMBL40650 | — | Kd | = | 12.88 | nM | 7.89 |
| CHEMBL291262 | — | Kd | = | 16.22 | nM | 7.79 |
| CHEMBL2112073 | — | Kd | = | 25.7 | nM | 7.59 |