Assay Detail
ADMET
CHEMBL637822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist dissociation constant in rat spleen, number of determinations => 3.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.49 | 9.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 9.69 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 8.60 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 8.31 |
| CHEMBL290387 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | Kd | = | 0.2042 | nM | 9.69 |
| CHEMBL611 | TERAZOSIN | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL709 | ALFUZOSIN | Kd | = | 4.898 | nM | 8.31 |
| CHEMBL290387 | — | Kd | = | 44.67 | nM | 7.35 |