Assay Detail
Binding
CHEMBL637898
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Binding affinity for rat Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.54 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200732 | — | — | 1 | 6.85 |
| CHEMBL201706 | — | — | 1 | 6.70 |
| CHEMBL203357 | — | — | 1 | 6.53 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200732 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL201706 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL203357 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 820.0 | nM | 6.09 |