Assay Detail
Binding
CHEMBL638319
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Inhibition of [3H]- NECA binding to adenosine receptor A2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.12 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315056 | — | — | 1 | 6.66 |
| CHEMBL139000 | (R)-PIA | — | 1 | 6.66 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.29 |
| CHEMBL284969 | — | — | 1 | 6.02 |
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 5.92 |
| CHEMBL610407 | — | — | 1 | 5.77 |
| CHEMBL312917 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315056 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL139000 | (R)-PIA | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL284969 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL610407 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL312917 | — | Ki | = | 3000.0 | nM | 5.52 |