Assay Detail
Binding
CHEMBL638323
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Binding affinity carried out with [3H]5'-(N-ethylcarbamoyl)-adenosine in the presence of 50 nM cyclopentyladenosine in rat striatal membranes against adenosine A2 receptor.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.83 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313780 | — | — | 1 | 6.39 |
| CHEMBL84363 | — | — | 1 | 6.37 |
| CHEMBL318537 | — | — | 1 | 6.36 |
| CHEMBL337073 | — | — | 1 | 6.32 |
| CHEMBL143710 | — | — | 1 | 6.24 |
| CHEMBL143622 | — | — | 1 | 6.24 |
| CHEMBL356458 | — | — | 1 | 6.23 |
| CHEMBL320668 | — | — | 1 | 6.16 |
| CHEMBL143567 | — | — | 1 | 6.00 |
| CHEMBL339270 | — | — | 1 | 5.96 |
| CHEMBL347787 | — | — | 1 | 5.92 |
| CHEMBL344992 | — | — | 1 | 5.85 |
| CHEMBL142410 | — | — | 1 | 5.82 |
| CHEMBL143565 | — | — | 1 | 5.75 |
| CHEMBL106937 | — | — | 1 | 5.57 |
| CHEMBL346382 | — | — | 1 | 5.48 |
| CHEMBL141486 | — | — | 1 | 5.40 |
| CHEMBL101800 | — | — | 1 | 5.20 |
| CHEMBL102371 | — | — | 1 | 4.85 |
| CHEMBL102372 | — | — | 1 | 4.54 |
| CHEMBL358971 | — | — | 1 | - |
| CHEMBL345983 | — | — | 1 | - |
| CHEMBL443274 | — | — | 1 | - |
| CHEMBL142576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313780 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL84363 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL318537 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL337073 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL143710 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL143622 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL356458 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL320668 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL143567 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL339270 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL347787 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL344992 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL142410 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL143565 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL106937 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL346382 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL141486 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL101800 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL102371 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL102372 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL358971 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL345983 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL443274 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL142576 | — | Ki | > | 100000.0 | nM | - |