Assay Detail
Binding
CHEMBL638445
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Experimental pIC50 values for the inhibition of acetylcholinesterase
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.02 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292314 | — | — | 1 | 8.00 |
| CHEMBL59782 | — | — | 1 | 7.88 |
| CHEMBL61715 | — | — | 1 | 7.55 |
| CHEMBL61561 | — | — | 1 | 7.34 |
| CHEMBL61533 | — | — | 1 | 7.06 |
| CHEMBL60119 | — | — | 1 | 7.00 |
| CHEMBL61221 | — | — | 1 | 6.89 |
| CHEMBL59628 | — | — | 1 | 6.77 |
| CHEMBL294525 | — | — | 1 | 6.53 |
| CHEMBL302842 | — | — | 1 | 6.45 |
| CHEMBL61849 | — | — | 1 | 6.41 |
| CHEMBL292121 | — | — | 1 | 6.36 |
| CHEMBL61986 | — | — | 1 | 6.33 |
| CHEMBL61930 | — | — | 1 | 6.32 |
| CHEMBL62084 | — | — | 1 | 6.26 |
| CHEMBL60167 | — | — | 1 | 6.17 |
| CHEMBL64465 | — | — | 1 | 6.13 |
| CHEMBL304447 | — | — | 1 | 5.92 |
| CHEMBL418643 | — | — | 1 | 5.80 |
| CHEMBL64615 | — | — | 1 | 5.78 |
| CHEMBL59977 | — | — | 1 | 5.52 |
| CHEMBL64815 | — | — | 1 | 5.43 |
| CHEMBL61486 | — | — | 1 | 5.42 |
| CHEMBL292122 | — | — | 1 | 5.41 |
| CHEMBL293842 | — | — | 1 | 5.37 |
| CHEMBL59844 | — | — | 1 | 5.34 |
| CHEMBL61506 | — | — | 1 | 5.32 |
| CHEMBL61929 | — | — | 1 | 5.29 |
| CHEMBL293896 | — | — | 1 | 5.27 |
| CHEMBL60308 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292314 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59782 | — | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL61715 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL61561 | — | IC50 | = | 45.71 | nM | 7.34 |
| CHEMBL61533 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL60119 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL61221 | — | IC50 | = | 128.82 | nM | 6.89 |
| CHEMBL59628 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL294525 | — | IC50 | = | 295.12 | nM | 6.53 |
| CHEMBL302842 | — | IC50 | = | 354.81 | nM | 6.45 |
| CHEMBL61849 | — | IC50 | = | 389.05 | nM | 6.41 |
| CHEMBL292121 | — | IC50 | = | 436.52 | nM | 6.36 |
| CHEMBL61986 | — | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL61930 | — | IC50 | = | 478.63 | nM | 6.32 |
| CHEMBL62084 | — | IC50 | = | 549.54 | nM | 6.26 |
| CHEMBL60167 | — | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL64465 | — | IC50 | = | 741.31 | nM | 6.13 |
| CHEMBL304447 | — | IC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL418643 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL64615 | — | IC50 | = | 1659.59 | nM | 5.78 |
| CHEMBL59977 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL64815 | — | IC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL61486 | — | IC50 | = | 3801.89 | nM | 5.42 |
| CHEMBL292122 | — | IC50 | = | 3890.45 | nM | 5.41 |
| CHEMBL293842 | — | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL59844 | — | IC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL61506 | — | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL61929 | — | IC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL293896 | — | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL60308 | — | IC50 | = | 5888.44 | nM | 5.23 |
| CHEMBL292480 | — | IC50 | = | 6456.54 | nM | 5.19 |
| CHEMBL59730 | — | IC50 | = | 6606.93 | nM | 5.18 |
| CHEMBL62085 | — | IC50 | = | 8128.31 | nM | 5.09 |
| CHEMBL294745 | — | IC50 | = | 28840.32 | nM | 4.54 |
| CHEMBL58122 | — | IC50 | = | 67608.3 | nM | 4.17 |