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Assay Detail

CHEMBL638446

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Binding
Inhibitory activity against acetylcholinesterase in human erythrocytes
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.
Bolognesi ML, Andrisano V, Bartolini M, Minarini A, Rosini M, Tumiatti V, Melchiorre C.
J Med Chem (2001) 44 : 105 -109
PubMed 11141093 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.25 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94 PHYSOSTIGMINE 3.0 1 7.75
CHEMBL274107 3 7.64
CHEMBL11805 CAPROCTAMINE 1 6.77
CHEMBL12324 1 5.74
CHEMBL11833 1 5.71
CHEMBL2113719 1 5.01
CHEMBL11514 1 4.79
CHEMBL268481 1 4.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94 PHYSOSTIGMINE IC50 = 17.78 nM 7.75
CHEMBL274107 IC50 = 22.91 nM 7.64
CHEMBL274107 IC50 = 29.51 nM 7.53
CHEMBL274107 IC50 = 74.13 nM 7.13
CHEMBL11805 CAPROCTAMINE IC50 = 169.82 nM 6.77
CHEMBL12324 IC50 = 1819.7 nM 5.74
CHEMBL11833 IC50 = 1949.84 nM 5.71
CHEMBL2113719 IC50 = 9772.37 nM 5.01
CHEMBL11514 IC50 = 16218.1 nM 4.79
CHEMBL268481 IC50 = 39810.72 nM 4.40