Assay Detail
Binding
CHEMBL638447
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Inhibitory activity on Acetylcholinesterase (AChE) from human erythrocytes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.27 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 6.77 |
| CHEMBL324975 | — | — | 1 | 5.85 |
| CHEMBL327100 | — | — | 1 | 5.47 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 5.27 |
| CHEMBL325740 | — | — | 1 | 5.21 |
| CHEMBL326308 | — | — | 1 | 4.80 |
| CHEMBL323655 | — | — | 1 | 4.48 |
| CHEMBL110045 | — | — | 1 | 4.27 |
| CHEMBL325505 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL324975 | — | IC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL327100 | — | IC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL27673 | METHOCTRAMINE | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL325740 | — | IC50 | = | 6165.95 | nM | 5.21 |
| CHEMBL326308 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL323655 | — | IC50 | = | 33113.11 | nM | 4.48 |
| CHEMBL110045 | — | IC50 | = | 53703.18 | nM | 4.27 |
| CHEMBL325505 | — | IC50 | = | 104712.85 | nM | - |