Assay Detail
Binding
CHEMBL638583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit liver.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Acyl-CoA:cholesterol acyltransferase (CHEMBL6141) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
RP 73163: A bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.14 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33780 | — | — | 1 | 7.36 |
| CHEMBL33661 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33780 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL33661 | — | IC50 | = | 122.0 | nM | 6.91 |