Assay Detail
Binding
CHEMBL638609
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In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 7.09 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542744 | — | — | 1 | 9.25 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 9.16 |
| CHEMBL138107 | — | — | 1 | 8.92 |
| CHEMBL140228 | — | — | 1 | 8.66 |
| CHEMBL140999 | — | — | 1 | 8.62 |
| CHEMBL433678 | — | — | 1 | 8.55 |
| CHEMBL342413 | — | — | 1 | 8.38 |
| CHEMBL138552 | — | — | 1 | 8.35 |
| CHEMBL126354 | — | — | 1 | 8.27 |
| CHEMBL140770 | — | — | 1 | 8.10 |
| CHEMBL139353 | — | — | 1 | 8.06 |
| CHEMBL141001 | — | — | 1 | 8.05 |
| CHEMBL138442 | — | — | 1 | 7.96 |
| CHEMBL105874 | — | — | 1 | 7.90 |
| CHEMBL141276 | — | — | 1 | 7.89 |
| CHEMBL140106 | — | — | 1 | 7.89 |
| CHEMBL140990 | — | — | 1 | 7.77 |
| CHEMBL140737 | — | — | 1 | 7.75 |
| CHEMBL141042 | — | — | 1 | 7.64 |
| CHEMBL106891 | — | — | 1 | 7.52 |
| CHEMBL55312 | — | — | 1 | 7.46 |
| CHEMBL127527 | — | — | 1 | 7.34 |
| CHEMBL340672 | — | — | 1 | 7.28 |
| CHEMBL141167 | — | — | 1 | 7.19 |
| CHEMBL340621 | — | — | 1 | 7.19 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.09 |
| CHEMBL333909 | — | — | 1 | 7.01 |
| CHEMBL141352 | — | — | 1 | 6.97 |
| CHEMBL56470 | — | — | 1 | 6.77 |
| CHEMBL340609 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542744 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL138107 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL140228 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL140999 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL433678 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL342413 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL138552 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL126354 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL140770 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL139353 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL141001 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL138442 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL105874 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL140106 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL141276 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL140990 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL140737 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL141042 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL106891 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL55312 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL127527 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL340672 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL340621 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL141167 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL95 | TACRINE | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL333909 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL141352 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL56470 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL340609 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL123909 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL141515 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL141622 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL336686 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL55014 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL141873 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL125578 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL141801 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL141810 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL141853 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL142014 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL141203 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL140328 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL142013 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL326868 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL140948 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL140769 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL140936 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL419184 | — | IC50 | = | 27000.0 | nM | 4.57 |