Assay Detail
Binding
CHEMBL638724
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Binding affinity against adenosine A1 receptor in bovine cortical membranes using [3H]CHA as radioligand
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 53 | 7.21 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97760 | — | — | 1 | 9.82 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 9.60 |
| CHEMBL102429 | — | — | 1 | 9.25 |
| CHEMBL97687 | — | — | 1 | 9.15 |
| CHEMBL104998 | — | — | 1 | 9.00 |
| CHEMBL329294 | — | — | 1 | 8.80 |
| CHEMBL97757 | — | — | 1 | 8.39 |
| CHEMBL102430 | — | — | 1 | 8.28 |
| CHEMBL97895 | — | — | 1 | 8.28 |
| CHEMBL97549 | — | — | 1 | 8.28 |
| CHEMBL313864 | — | — | 1 | 8.28 |
| CHEMBL104999 | — | — | 1 | 8.17 |
| CHEMBL102178 | — | — | 1 | 8.14 |
| CHEMBL316630 | — | — | 1 | 8.00 |
| CHEMBL95384 | — | — | 1 | 7.96 |
| CHEMBL321769 | — | — | 1 | 7.82 |
| CHEMBL97037 | — | — | 1 | 7.80 |
| CHEMBL97337 | — | — | 1 | 7.77 |
| CHEMBL323303 | — | — | 1 | 7.64 |
| CHEMBL97896 | — | — | 1 | 7.58 |
| CHEMBL97624 | — | — | 1 | 7.55 |
| CHEMBL102753 | — | — | 1 | 7.32 |
| CHEMBL103150 | — | — | 1 | 7.32 |
| CHEMBL103559 | — | — | 1 | 7.30 |
| CHEMBL418797 | — | — | 1 | 7.16 |
| CHEMBL329293 | — | — | 1 | 7.10 |
| CHEMBL94538 | — | — | 1 | 7.00 |
| CHEMBL102491 | — | — | 1 | 6.80 |
| CHEMBL103588 | — | — | 1 | 6.68 |
| CHEMBL102974 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97760 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL102429 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL97687 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL104998 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL329294 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL97757 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL102430 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL97895 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL97549 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL313864 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL104999 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL102178 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL316630 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL95384 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL321769 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL97037 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL97337 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL323303 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL97896 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL97624 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL102753 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL103150 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL103559 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL418797 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL329293 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL94538 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL102491 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL103588 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL102974 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL317411 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL17127 | SCH-58261 | Ki | = | 357.0 | nM | 6.45 |
| CHEMBL105000 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL415697 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL97665 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL96576 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL97778 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL100121 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL98227 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL103796 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL323288 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL328214 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL319580 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL97344 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL103553 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL96617 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL441815 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL321330 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL103278 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL102126 | — | Ki | > | 10000.0 | nM | - |