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Compound Detail

CHEMBL95384

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Cc1ccc2c(O)cc(-c3ccccc3F)nc2n1

Basic Information

ChEMBL ID CHEMBL95384
Phase Preclinical
Structure Type MOL
InChI Key AXHXSGOIYWBQTM-UHFFFAOYSA-N
4
Targets
7
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

254.3
MW (Da)
3.45
ALogP
3
HBA
1
HBD
46.0
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H11FN2O
MW 254.26
Aromatic Rings 3
Heavy Atoms 19
NP-Likeness -0.95

Activity Summary

Ki 7 meas. best 7.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL4975
Ki 7.96 7.96 11.0 2
Adenosine receptor A2a
CHEMBL251
Ki 7.4 6.6867 40.0 3
Adenosine receptor A1
CHEMBL226
Ki 6.31 6.31 490.0 1
Adenosine receptor A3
CHEMBL3360
Ki 5.34 5.34 4600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10956189 10.1021/jm990321p Unchecked 3
15163184 10.1021/jm030977p Adenosine receptor A1 2
15163184 10.1021/jm030977p Adenosine receptor A2a 2
15163184 10.1021/jm030977p Unchecked 1
15163184 10.1021/jm030977p Adenosine receptors; A1 & A2 1
10956189 10.1021/jm990321p Adenosine receptor A1 1
10956189 10.1021/jm990321p Adenosine receptor A2a 1
10956189 10.1021/jm990321p Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine