Assay Detail
Binding
CHEMBL643493
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Binding affinity against adenosine A1 receptor in human cortical membranes using [3H]CHA as radioligand
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 53 | 5.87 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 8.17 |
| CHEMBL97760 | — | — | 1 | 6.52 |
| CHEMBL97687 | — | — | 1 | 6.44 |
| CHEMBL97549 | — | — | 1 | 6.37 |
| CHEMBL17127 | SCH-58261 | — | 1 | 6.33 |
| CHEMBL95384 | — | — | 1 | 6.31 |
| CHEMBL97624 | — | — | 1 | 6.25 |
| CHEMBL104999 | — | — | 1 | 6.04 |
| CHEMBL102753 | — | — | 1 | 6.03 |
| CHEMBL102429 | — | — | 1 | 6.01 |
| CHEMBL103559 | — | — | 1 | 6.00 |
| CHEMBL97037 | — | — | 1 | 5.89 |
| CHEMBL97757 | — | — | 1 | 5.85 |
| CHEMBL103150 | — | — | 1 | 5.82 |
| CHEMBL329293 | — | — | 1 | 5.70 |
| CHEMBL104998 | — | — | 1 | 5.70 |
| CHEMBL329294 | — | — | 1 | 5.70 |
| CHEMBL97337 | — | — | 1 | 5.70 |
| CHEMBL418797 | — | — | 1 | 5.66 |
| CHEMBL321769 | — | — | 1 | 5.66 |
| CHEMBL97895 | — | — | 1 | 5.58 |
| CHEMBL316630 | — | — | 1 | 5.51 |
| CHEMBL102430 | — | — | 1 | 5.47 |
| CHEMBL313864 | — | — | 1 | 5.41 |
| CHEMBL323303 | — | — | 1 | 5.40 |
| CHEMBL103588 | — | — | 1 | 5.39 |
| CHEMBL102178 | — | — | 1 | 5.12 |
| CHEMBL96576 | — | — | 1 | 5.06 |
| CHEMBL105000 | — | — | 1 | 5.00 |
| CHEMBL415697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL97760 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL97687 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL97549 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL17127 | SCH-58261 | Ki | = | 463.0 | nM | 6.33 |
| CHEMBL95384 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL97624 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL104999 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL102753 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL102429 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL103559 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL97037 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL97757 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL103150 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL97337 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL104998 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL329294 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL329293 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL418797 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL321769 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL97895 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL316630 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL102430 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL313864 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL323303 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL103588 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL102178 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL96576 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL105000 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL323288 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL97896 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL103796 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL317411 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL103553 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL98227 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL97665 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL100121 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL102017 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL97778 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL96617 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL102126 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL103278 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL441815 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL321330 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL328334 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL319580 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL97344 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL97904 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL94538 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL415697 | — | Ki | > | 10000.0 | nM | - |