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Assay Detail

CHEMBL639509

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adenosine A2 receptor (CHEMBL2094257)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

2-aralkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.
Ueeda M, Thompson RD, Arroyo LH, Olsson RA.
J Med Chem (1991) 34 : 1340 -1344
PubMed 2016708 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 8.11 9.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL606080 1 9.06
CHEMBL605463 1 8.85
CHEMBL606081 1 8.72
CHEMBL605876 1 8.58
CHEMBL606092 1 8.55
CHEMBL604837 1 8.30
CHEMBL603587 1 8.26
CHEMBL604212 1 8.20
CHEMBL605257 1 8.02
CHEMBL605256 1 8.01
CHEMBL477 ADENOSINE 4.0 1 7.29
CHEMBL2311199 1 7.21
CHEMBL605672 1 6.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL606080 EC50 = 0.871 nM 9.06
CHEMBL605463 EC50 = 1.413 nM 8.85
CHEMBL606081 EC50 = 1.905 nM 8.72
CHEMBL605876 EC50 = 2.63 nM 8.58
CHEMBL606092 EC50 = 2.818 nM 8.55
CHEMBL604837 EC50 = 5.012 nM 8.30
CHEMBL603587 EC50 = 5.495 nM 8.26
CHEMBL604212 EC50 = 6.31 nM 8.20
CHEMBL605257 EC50 = 9.55 nM 8.02
CHEMBL605256 EC50 = 9.772 nM 8.01
CHEMBL477 ADENOSINE EC50 = 51.29 nM 7.29
CHEMBL2311199 EC50 = 61.66 nM 7.21
CHEMBL605672 EC50 = 416.87 nM 6.38