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Assay Detail

CHEMBL639512

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Coronary arteries vasodilation at the adenosine A2 receptor in langendorff guinea pig heart preparation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adenosine A2 receptor (CHEMBL2094257)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.
Ueeda M, Thompson RD, Arroyo LH, Olsson RA.
J Med Chem (1991) 34 : 1334 -1339
PubMed 2016707 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 7.86 9.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2094089 1 9.35
CHEMBL606093 1 8.99
CHEMBL605254 1 8.67
CHEMBL603589 1 8.41
CHEMBL605247 1 8.35
CHEMBL1256672 1 7.74
CHEMBL285819 1 7.60
CHEMBL477 ADENOSINE 4.0 1 7.29
CHEMBL68738 N6-CYCLOPENTYLADENOSINE 1 7.20
CHEMBL605673 1 6.75
CHEMBL2311198 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2094089 EC50 = 0.4467 nM 9.35
CHEMBL606093 EC50 = 1.023 nM 8.99
CHEMBL605254 EC50 = 2.138 nM 8.67
CHEMBL603589 EC50 = 3.89 nM 8.41
CHEMBL605247 EC50 = 4.467 nM 8.35
CHEMBL1256672 EC50 = 18.2 nM 7.74
CHEMBL285819 EC50 = 25.12 nM 7.60
CHEMBL477 ADENOSINE EC50 = 51.29 nM 7.29
CHEMBL68738 N6-CYCLOPENTYLADENOSINE EC50 = 63.1 nM 7.20
CHEMBL605673 EC50 = 177.83 nM 6.75
CHEMBL2311198 EC50 = 691.83 nM 6.16