Assay Detail
Binding
CHEMBL639638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of (R)-N6-([3H]-phenylisopropyl) adenosine binding to adenosine A1 receptor from rat cortical membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.57 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 9.05 |
| CHEMBL273094 | XANTHINE AMINE CONGENER | — | 1 | 8.92 |
| CHEMBL22099 | — | — | 1 | 5.64 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.89 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL273094 | XANTHINE AMINE CONGENER | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL22099 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL113 | CAFFEINE | Ki | = | 44000.0 | nM | 4.36 |