Assay Detail
Binding
CHEMBL639745
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Displacement of [3H]DPCPX from Adenosine A1 receptor of rat cortical membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.08 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62078 | — | — | 1 | 7.75 |
| CHEMBL60027 | — | — | 1 | 7.66 |
| CHEMBL305322 | — | — | 1 | 7.50 |
| CHEMBL61836 | — | — | 1 | 7.48 |
| CHEMBL294175 | — | — | 1 | 7.44 |
| CHEMBL60334 | — | — | 1 | 7.41 |
| CHEMBL61381 | — | — | 1 | 7.24 |
| CHEMBL293437 | — | — | 1 | 7.23 |
| CHEMBL60156 | — | — | 1 | 7.12 |
| CHEMBL61222 | — | — | 1 | 7.07 |
| CHEMBL59978 | — | — | 1 | 6.78 |
| CHEMBL293635 | — | — | 1 | 5.87 |
| CHEMBL62075 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62078 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL60027 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL305322 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL61836 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL294175 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL60334 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL61381 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL293437 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL60156 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL61222 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL59978 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL293635 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL62075 | — | Ki | = | 3000.0 | nM | 5.52 |