Assay Detail
Binding
CHEMBL639746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of adenosine A1 receptor binding to rat brain
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.80 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88439 | — | — | 1 | 9.05 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 8.92 |
| CHEMBL88815 | — | — | 1 | 8.85 |
| CHEMBL284969 | — | — | 1 | 8.82 |
| CHEMBL316112 | — | — | 1 | 8.44 |
| CHEMBL430459 | — | — | 1 | 8.40 |
| CHEMBL423315 | — | — | 1 | 8.38 |
| CHEMBL91304 | — | — | 1 | 8.21 |
| CHEMBL88841 | — | — | 1 | 8.03 |
| CHEMBL88911 | — | — | 1 | 8.03 |
| CHEMBL328097 | — | — | 1 | 8.00 |
| CHEMBL327195 | — | — | 1 | 7.96 |
| CHEMBL433009 | — | — | 1 | 7.96 |
| CHEMBL413506 | — | — | 1 | 7.96 |
| CHEMBL314730 | — | — | 1 | 7.89 |
| CHEMBL313306 | — | — | 1 | 7.88 |
| CHEMBL92311 | — | — | 1 | 7.82 |
| CHEMBL88963 | — | — | 1 | 7.77 |
| CHEMBL264013 | — | — | 1 | 7.52 |
| CHEMBL92210 | — | — | 1 | 7.47 |
| CHEMBL89572 | — | — | 1 | 7.26 |
| CHEMBL89543 | — | — | 1 | 6.74 |
| CHEMBL329189 | — | — | 1 | 6.41 |
| CHEMBL91780 | — | — | 1 | 6.40 |
| CHEMBL91894 | — | — | 1 | 4.89 |
| CHEMBL313806 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88439 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL88815 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL284969 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL316112 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL430459 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL423315 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL91304 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL88841 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL88911 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL328097 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL327195 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL433009 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL413506 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL314730 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL313306 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL92311 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL88963 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL264013 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL92210 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL89572 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL89543 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL329189 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL91780 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL91894 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL313806 | — | Ki | > | 3000.0 | nM | - |