Assay Detail
Functional
CHEMBL640174
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Effective concentration required for prolongation of the stimulus-QRS interval by 50% of the maximum response at the A1 adenosine receptor in langendorff guinea pig heart preparation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-aralkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 4.81 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 5.47 |
| CHEMBL604212 | — | — | 1 | 5.34 |
| CHEMBL605257 | — | — | 1 | 5.15 |
| CHEMBL604837 | — | — | 1 | 5.08 |
| CHEMBL605256 | — | — | 1 | 4.85 |
| CHEMBL605463 | — | — | 1 | 4.71 |
| CHEMBL606092 | — | — | 1 | 4.70 |
| CHEMBL2311199 | — | — | 1 | 4.70 |
| CHEMBL603587 | — | — | 1 | 4.66 |
| CHEMBL606080 | — | — | 1 | 4.59 |
| CHEMBL606081 | — | — | 1 | 4.46 |
| CHEMBL605876 | — | — | 1 | 4.45 |
| CHEMBL605672 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | EC50 | = | 3388.44 | nM | 5.47 |
| CHEMBL604212 | — | EC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL605257 | — | EC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL604837 | — | EC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL605256 | — | EC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL605463 | — | EC50 | = | 19498.45 | nM | 4.71 |
| CHEMBL606092 | — | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2311199 | — | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL603587 | — | EC50 | = | 21877.62 | nM | 4.66 |
| CHEMBL606080 | — | EC50 | = | 25703.96 | nM | 4.59 |
| CHEMBL606081 | — | EC50 | = | 34673.69 | nM | 4.46 |
| CHEMBL605876 | — | EC50 | = | 35481.34 | nM | 4.45 |
| CHEMBL605672 | — | EC50 | = | 46773.51 | nM | 4.33 |