Assay Detail
Binding
CHEMBL640253
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Inhibition of specific binding of [3H]CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.27 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328953 | — | — | 1 | 8.10 |
| CHEMBL329774 | — | — | 1 | 8.05 |
| CHEMBL327708 | — | — | 1 | 8.00 |
| CHEMBL91604 | — | — | 1 | 7.96 |
| CHEMBL88128 | — | — | 1 | 7.70 |
| CHEMBL90627 | — | — | 1 | 7.70 |
| CHEMBL94105 | — | — | 1 | 7.22 |
| CHEMBL314539 | — | — | 1 | 7.10 |
| CHEMBL90702 | — | — | 1 | 7.06 |
| CHEMBL90024 | — | — | 1 | 7.05 |
| CHEMBL92906 | — | — | 1 | 6.22 |
| CHEMBL329810 | — | — | 1 | 6.16 |
| CHEMBL330335 | — | — | 1 | 6.16 |
| CHEMBL89920 | — | — | 1 | 6.10 |
| CHEMBL91505 | — | — | 1 | 5.92 |
| CHEMBL91284 | — | — | 1 | 5.70 |
| CHEMBL446355 | — | — | 1 | 5.66 |
| CHEMBL90037 | — | — | 1 | 5.60 |
| CHEMBL90720 | — | — | 1 | 5.58 |
| CHEMBL93600 | — | — | 1 | 5.46 |
| CHEMBL328033 | — | — | 1 | 5.46 |
| CHEMBL93674 | — | — | 1 | 5.40 |
| CHEMBL90745 | — | — | 1 | 5.38 |
| CHEMBL90298 | — | — | 1 | 5.20 |
| CHEMBL90937 | — | — | 1 | 5.16 |
| CHEMBL91135 | — | — | 1 | 4.96 |
| CHEMBL89939 | — | — | 1 | 4.85 |
| CHEMBL94284 | — | — | 1 | 4.77 |
| CHEMBL94234 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328953 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL329774 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL327708 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL91604 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL88128 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL90627 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL94105 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL314539 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL90702 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL90024 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL92906 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL329810 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL330335 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL89920 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL91505 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL91284 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL446355 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL90037 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL90720 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL93600 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL328033 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL93674 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL90745 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL90298 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL90937 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL91135 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL89939 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL94284 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL94234 | — | IC50 | > | 100000.0 | nM | - |