Assay Detail
Binding
CHEMBL640254
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Inhibitory concentration against [3H]DPCPX binding to Adenosine A1 receptor from DDT1 MF2 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | DDT1 MF2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New irreversible adenosine A(1) antagonists based on FSCPX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.97 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107646 | — | — | 1 | 8.41 |
| CHEMBL107499 | — | — | 1 | 8.06 |
| CHEMBL327708 | — | — | 1 | 7.93 |
| CHEMBL108552 | — | — | 1 | 7.78 |
| CHEMBL321218 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107646 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL107499 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL327708 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL108552 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL321218 | — | IC50 | = | 21.0 | nM | 7.68 |