Assay Detail
Binding
CHEMBL640256
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Inhibition of [3H]-DPCPX binding to adenosine A1 receptor (AR).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.20 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321218 | — | — | 1 | 7.68 |
| CHEMBL144360 | — | — | 1 | 7.60 |
| CHEMBL148098 | — | — | 1 | 7.00 |
| CHEMBL147156 | — | — | 1 | 6.95 |
| CHEMBL359066 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321218 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL144360 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL148098 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL147156 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL359066 | — | IC50 | = | 165.0 | nM | 6.78 |