Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL640258

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Specific binding of [3H]CPX to the A1-adenosine receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cricetulus griseus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine receptor A1 (CHEMBL226)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors.
Scammells PJ, Baker SP, Belardinelli L, Olsson RA.
J Med Chem (1994) 37 : 2704 -2712
PubMed 8064798 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 13 8.99 9.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL89939 1 9.16
CHEMBL88128 1 9.15
CHEMBL329810 1 9.13
CHEMBL93600 1 9.10
CHEMBL328033 1 9.09
CHEMBL90720 1 9.07
CHEMBL90745 1 8.96
CHEMBL330335 1 8.96
CHEMBL91604 1 8.96
CHEMBL314539 1 8.89
CHEMBL94284 1 8.89
CHEMBL329774 1 8.82
CHEMBL89920 1 8.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL89939 Kd = 0.69 nM 9.16
CHEMBL88128 Kd = 0.71 nM 9.15
CHEMBL329810 Kd = 0.74 nM 9.13
CHEMBL93600 Kd = 0.79 nM 9.10
CHEMBL328033 Kd = 0.82 nM 9.09
CHEMBL90720 Kd = 0.86 nM 9.07
CHEMBL90745 Kd = 1.1 nM 8.96
CHEMBL330335 Kd = 1.1 nM 8.96
CHEMBL91604 Kd = 1.1 nM 8.96
CHEMBL314539 Kd = 1.3 nM 8.89
CHEMBL94284 Kd = 1.3 nM 8.89
CHEMBL329774 Kd = 1.5 nM 8.82
CHEMBL89920 Kd = 1.8 nM 8.74