Assay Detail
Binding
CHEMBL640266
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Binding affinity for Adenosine A1 receptor in corpora striata of rats using [3H]NECA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.34 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 8.34 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 4.62 | nM | 8.34 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 462.0 | nM | 6.33 |