Assay Detail
Binding
CHEMBL640282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rat ATP-citrate lyase activity by the maleate dehydrogenase catalyzed reduction of oxaloacetate by NADH.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 4.77 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121948 | — | — | 1 | 5.92 |
| CHEMBL118918 | — | — | 1 | 5.58 |
| CHEMBL333756 | — | — | 1 | 5.54 |
| CHEMBL116883 | — | — | 1 | 5.54 |
| CHEMBL119690 | — | — | 1 | 5.14 |
| CHEMBL120840 | — | — | 1 | 5.14 |
| CHEMBL118149 | — | — | 1 | 5.13 |
| CHEMBL120379 | — | — | 1 | 5.00 |
| CHEMBL118890 | — | — | 1 | 4.98 |
| CHEMBL118737 | — | — | 1 | 4.92 |
| CHEMBL120848 | — | — | 1 | 4.75 |
| CHEMBL118961 | — | — | 1 | 4.68 |
| CHEMBL120795 | — | — | 1 | 4.60 |
| CHEMBL422789 | — | — | 1 | 4.60 |
| CHEMBL120604 | — | — | 1 | 4.51 |
| CHEMBL120510 | — | — | 1 | 4.48 |
| CHEMBL333104 | — | — | 1 | 4.42 |
| CHEMBL118670 | — | — | 1 | 4.19 |
| CHEMBL331542 | — | — | 1 | 4.17 |
| CHEMBL120202 | — | — | 1 | 4.16 |
| CHEMBL119988 | — | — | 1 | 4.15 |
| CHEMBL332398 | — | — | 1 | 4.12 |
| CHEMBL118920 | — | — | 1 | 4.06 |
| CHEMBL118632 | — | — | 1 | - |
| CHEMBL116658 | — | — | 1 | - |
| CHEMBL325929 | — | — | 1 | - |
| CHEMBL333172 | — | — | 1 | - |
| CHEMBL120624 | — | — | 1 | - |
| CHEMBL120378 | — | — | 1 | - |
| CHEMBL116544 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121948 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL118918 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL116883 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL333756 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL119690 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL120840 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL118149 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL120379 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL118890 | — | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL118737 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL120848 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL118961 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL120795 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL422789 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL120604 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL120510 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL333104 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL118670 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL331542 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL120202 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL119988 | — | Ki | = | 71000.0 | nM | 4.15 |
| CHEMBL332398 | — | Ki | = | 76000.0 | nM | 4.12 |
| CHEMBL118920 | — | Ki | = | 88000.0 | nM | 4.06 |
| CHEMBL418864 | — | Ki | = | 130000.0 | nM | - |
| CHEMBL331020 | — | Ki | = | 420000.0 | nM | - |
| CHEMBL331482 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL118935 | — | Ki | = | 175000.0 | nM | - |
| CHEMBL120603 | — | Ki | = | 500000.0 | nM | - |
| CHEMBL121149 | — | Ki | = | 410000.0 | nM | - |
| CHEMBL331622 | — | Ki | = | 178000.0 | nM | - |
| CHEMBL116544 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL120378 | — | Ki | = | 131000.0 | nM | - |
| CHEMBL120624 | — | Ki | = | 420000.0 | nM | - |
| CHEMBL333172 | — | Ki | = | 300000.0 | nM | - |
| CHEMBL325929 | — | Ki | = | 490000.0 | nM | - |
| CHEMBL116658 | — | Ki | = | 226000.0 | nM | - |
| CHEMBL118632 | — | Ki | = | 110000.0 | nM | - |