Assay Detail
Functional
CHEMBL640299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
G-protein activation in human Adenosine A2A receptor expressed in CHO cells using cAMP assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.77 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319387 | — | — | 1 | 8.00 |
| CHEMBL2113605 | — | — | 1 | 6.30 |
| CHEMBL2113595 | — | — | 1 | 6.16 |
| CHEMBL2113604 | — | — | 1 | 6.10 |
| CHEMBL2113592 | — | — | 1 | 5.96 |
| CHEMBL2113601 | — | — | 1 | 5.44 |
| CHEMBL2113588 | — | — | 1 | 5.30 |
| CHEMBL2113519 | — | — | 1 | 5.27 |
| CHEMBL2113580 | — | — | 1 | 5.12 |
| CHEMBL2113606 | — | — | 1 | 4.98 |
| CHEMBL2113581 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319387 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2113605 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2113595 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2113604 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2113592 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2113601 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2113588 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2113519 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2113580 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL2113606 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL2113581 | — | EC50 | = | 12900.0 | nM | 4.89 |