Assay Detail
Binding
CHEMBL640306
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Inhibitory activity against cyclic AMP production in rat Adenosine A2A receptor assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.21 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27508 | — | — | 1 | 9.00 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 6.34 |
| CHEMBL440115 | FK453 | 1.0 | 1 | 4.95 |
| CHEMBL52735 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27508 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL440115 | FK453 | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL52735 | — | IC50 | = | 27500.0 | nM | 4.56 |