Assay Detail
Binding
CHEMBL640322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Adenylate cyclase activity in rat fat cell membrane at adenosine A1 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.22 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139000 | (R)-PIA | — | 1 | 7.40 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 7.24 |
| CHEMBL464859 | NECA | — | 1 | 6.70 |
| CHEMBL2113390 | — | — | 1 | 6.44 |
| CHEMBL606016 | — | — | 1 | 6.20 |
| CHEMBL605008 | — | — | 1 | 6.02 |
| CHEMBL2113389 | — | — | 1 | 6.01 |
| CHEMBL2113396 | — | — | 1 | 5.82 |
| CHEMBL2113387 | — | — | 1 | 5.80 |
| CHEMBL2113391 | — | — | 1 | 5.62 |
| CHEMBL115824 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139000 | (R)-PIA | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL464859 | NECA | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2113390 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL606016 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL605008 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL2113389 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2113396 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2113387 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2113391 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL115824 | — | IC50 | = | 6700.0 | nM | 5.17 |